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Valproate

VALPROATE

Valproate is medications primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.

Valproate

This medication, Valproate (VPA) is also known by many other names like divalproex sodium, sodium valproate, and valporic acid. It is commonly used for the treatment of bipolar disorder, epilepsy, and also for avoiding migraine headaches. Any kind of seizures be it generalized, partial or absence, can be prevented using this drug. It is administered either orally or intravenously. It goes by many other trade names like epilim, vilapro, stavzor, depakote, and convulex. It belongs to the pregnancy category D as it might cause some serious abnormalities in the new born baby.

Valproate was made first in the year 1881 and it came into use in the year 1962. It is listed as an important medication is the World Health Organisation's List of Essential Medicines.

Composition of Valproate

The active ingredient in this medication is Sodium Valproate. The other inactive ingredients involved in the 250 mg capsules are:

  • Titanium dioxide
  • Propylparaben
  • Methylparaben
  • Iron oxide
  • Glycerine
  • Gelatine
  • FD&C Yellow No. 6
  • Corn oil

The inactive ingredients in the oral solution are:

  • Artificial or natural colours
  • Water
  • Sucrose
  • Sorbitol
  • Propylparaben
  • Methylparaben
  • Glycerine
  • FD&C Red No. 40

Uses of Valproate

This medication is useful in treating seizure disorders, mood/mental conditions (like the manic phase in bipolar disorder), and also works in preventing migraine headaches. The balance is restored in some neurotransmitters in the brain which help in the treatment process.

Side-effects of Valproate

The side-effects that may occur due to the consumption or usage of this drug are many. A variety of them are discussed below:

  • Bleeding gums
  • Tarry, black stools
  • Crying
  • Dementia
  • Delusions
  • Hoarseness or cough
  • Confusion
  • Blood in the stools or urine
  • Swelling or bloating of the feet, lower legs, hands, arms, and face
  • Diarrhoea
  • Depersonalization
  • Dsyphoria
  • Euphoria
  • Chills or fever
  • Joint pain
  • Nausea
  • Mental depression
  • Side or lower back pain
  • Loss of appetite
  • Headache
  • Runny nose
  • Rapid gain of weight
  • Shivering
  • Shakiness in the feet, hands, arms, or legs
  • Rapid changes in the mood
  • Paranoia
  • Difficult or painful urination
  • Sore throat
  • Trouble in sleeping
  • Abnormal dreams
  • Anxiety
  • Vomiting
  • Unusual weakness or tiredness
  • Unusual bruising or bleeding
  • Tightness experienced in the chest
  • Change in personality
  • Constipation
  • Cold sweats
  • Unsteadiness or clumsiness
  • Darkened urine

Contraindications of Valproate

There are many medical conditions under which Valproate must not be prescribed to the patient as it might cause potential harm. They are mentioned below:

  • Allergy to Valproic acid analogues
  • Depression
  • Poisoning caused by Valproic Acid
  • Having any kind of thoughts regarding suicide
  • Ornithine Carbomayltransferase Deficiency
  • Liver problems
  • Pregnancy

Valproate and Pregnancy

This medication has been assigned to the pregnancy category D. There have been instances of serious impairments in the baby, hence it is contraindicated to pregnant women.

Tags: buy valproate online, generic valporic acid, valproate 500mg.
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