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Xarelto

XARELTO

Xarelto (rivaroxaban) is a highly effective, oral anticoagulant developed to prevent and treat dangerous blood clots.

Xarelto

Xarelto is the brand name for Rivaroxaban. It is an anticoagulant that prevents the formation of blood clots. It usually prevent clot formation in the lungs known as pulmonary embolism also Deep vein thrombosis due to blood clot.

Mechanism of action (MOA)

Rivaroxaban is an oxazolidinone that works by inhibiting the factor Xa and factor Xa bound with prothrombinase complex. Factor Xa inhibition interrupts the intrinsic and extrinsic pathway of blood coagulation that will stop the formation of thrombin or thrombi.

Uses of Xarelto

The most important use of Xarelto is to prevent formation of a clot or thrombi in the blood.

In non valvular atrial fibrillation it is as effective as warfarin in preventing embolic event and non hemorrhagic strokes.

It has been very useful in preventing venous thromboembolism in people who have gone through hip replacement surgery or knee replacement surgery.

Dosage and Administration

Xarelto is taken orally because it is in tablet form.

If the patient is taking Xarelto for risk of stroke in non valvular atrial fibrillation with crcl>50ml/min 20mg once daily with evening meal

Also with crcl 15 to 50ml/min with evening meal.

For treatment of DVT and PE 15mg for 21 days twice daily after 21 days increase it with 20mg daily.

For recurrence of DVT and PE 20mg once daily with food.

For prophylaxis purpose of DVT and PE after hip or knee replacement surgery 10mg once daily for 35 days and 10 mg once daily for 21 days.

Side-Effects of Xarelto

Common side-effects are

1) Back pain

2) Dizziness

3) Headache

4) Bladder or bowel dysfunction

5) Leg weakness

6) Difficulty in breathing or swallowing

7) Haemorrhaging

8) Bleeding from rectum

9) Numbness

10) Tingling sensation

11) Loss of ability to control movement

12) Reduced platelet count

13) Abdominal bleeds

14) Abnormal liver function

15) Easy bruising

16) Coughing up blood

17) Persistent nosebleeds

18) Black tarry stools

19) Heavy menstrual flow

20) Paralysis

Serious side-effects

1) Pain while urinating

2) Sores

3) Ulcers

4) Tightness in chest

5) Yellow skin or eyes

Pregnancy and Breast-Feeding

During pregnancy use the medication with extreme caution in case of bleeding or haemorrhaging and seek medical advice. It is not known if women with high risk pregnancy can use it or not because there is no antidote for it.

For nursing mothers please consult your doctor regarding queries.

Precaution and Warning

Please give your full personal and family history to the doctor. If you have any allergy or if you had any recent surgery please let the doctor know. Specially if you have liver disease, kidney disease or bleeding problems, stroke, frequent fall or injury.

Please limit your alcohol intake as it causes stomach bleeding.

Drug Interaction

Some drugs may interact with Xarelto and can change the course of the drug. Drugs like Warfarin, NSAIDS, Heparin, Clopidogrel and SSRIs like Zoloft and Prozac. They can increase bleeding in the patient.

Tags: buy xarelto online, generic rivaroxaban, xarelto 20mg.
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