Enzyme’s Role in Burning Calories during Dieting and Obesity
It is natural to wonder why overweight people burn less amount of calories or why dieting stagnates weight loss after a point of time. In both scenarios, the human body is attempting to defend the weight by making necessary regulations in the energy expenditure. In a new research paper, a group of researchers were capable to find that an enzyme, an enzyme known as (TBK1) has a major role to play in controlling the energy spending during fasting and fatness.
This has been a mystery since a long time. Human bodies are known to be efficient at storing energy for the purpose of conservation at times of emergency, according to Alan Saltiel from the UC San Diego Institute for Diabetes and Metabolic Health. The energy expenditure is repressed in order to conserve it. This is a natural mechanism of the body to make sure that the individual is able to survive during a famine.
The paper was published in a journal called Cell on the 8th of February. Researchers from the University Of California San Diego School Of Medicine identified a specific enzyme to have a crucial role in controlling energy expenditure, or burning calories, during fasting or obesity.
Two important observations were made while studying the slowing down of metabolism rate, according to Saltiel. There are two new feedback loops that work together for self-regulating the system. The mechanism is similar to a home thermostat that knows how to turn the heater off and on according to the changes in temperature.
With the help of mouse models, researchers discovered the first loop where chronic stress usually instigated by obesity can cause inflammation leading to the activation of a pathway called NFKB. This pathway is known to induce genes linked with obesity and inflammation including TBK1. After TBK1 is activated, it turns the AMPK down, known to be the master regulator of energy expenditure. This can reduce the ability of the cell to burn calories for storing fat. This mechanism is incorporated in obesity for reducing energy expenditure.
AMPK also has the potential to sense changes in the level of energy at the time of fasting which increases the expenditure by commanding the cells, particularly adipocytes (fat cells) for burning fat. But, as soon as the AMPK is activated, TBK1 is also initiated which later inhibits the initial role of AMPK in burning the fat.
Saltiel mentioned that the feedback loop has the potential to block energy expenditure using fasting and inflammation. The energy expenditure was brought back to normal when the TBK1 was deleted from the fat cells in mice. But, it also resulted in another feedback loop which increased inflammation.
Deleting the TBK1 has the potential to increase weight loss, but can increase inflammation in obese mice. But, normal weight mice did not exhibit any such signs.
One of the possible inhibitors of TBK1 is amlexanox, an anti-allergic and anti-inflammatory drug used for the treatment of asthma. When this drug was administered to obese mice, it resulted in weight loss but their insulin sensitivity increased.
This paper tried to show how amlexanox can be effective in inhibiting the enzyme preventing weight loss.
Health Information Articles
- Asthma Drug Could Be a Potential Drug for Treating Aortic Aneurysm
- Ankylosing Spondylitis
- Parkinson`S Effect On The Gut
- Hepatitis B
- Optimize Cholesterol Level
- Lump Isn’t Always the First Sign of Breast Cancer
- Calcium And Vitamin D Supplements Do Not Help In Lowering Risk Of Bone Fracture
- A Simple Molecule Can Help in Overcoming Pre-Diabetes
- Bone Repair Process Trigger Through Nanophenomenon
- Blood Sodium Levels Impacts Cognition in Late Adulthood
- Cervical Spondylosis
- Enzyme’s Role in Burning Calories during Dieting and Obesity
- Calcium Pills May Facilitate Artery Build-up
- Benign Fasciculation Syndrome And Causes
- Certain Genes Can Help Bladder Cancer And Its Treatment
- Botox Injections Could Help With Migraine Pain in Children and Adolescents
- Supervised Injection Facilities to Help In Reducing Overdose Deaths
- Study Suggest There is a Role of Vitamin D3 to Heal or Prevent Cardiovascular Injuries
- Virus Ebola
- Antiemetic Drugs - Types and Side Effects
- Drugs To Reduce Harmfully Fat Cells
- Diabetic Foot Ulcers and Its Impact
- Have We Invited Our Suffering?
- According To Scientists, The Flavours Of E-Cigarette Are Toxic To The White Blood Cells
- Birth Control Pills Enhance the Risk of Breast Cancer
- Commonly Used Heartburn Medications Liked to Kidney Trouble
- Better Anti-Thrombotic Medication Target Identified
- Antioxidants Might Not Curb Dementia
- Does Asthma Have A Cure?
- New Drug Could Help In Fighting TB
- How to ease the Side Effects of ADHD Drugs in Adults
- Association Between Five Vascular Diseases And A Common Single Genetic Variant
- Melanoma Survival And Impact Of Existing Drugs
- Home Remedies for Hemorrhoids!
- Atrial Fibrillation
- Prevention of Osteopenia!