Urecholine is the brand name for Bethanechol. It is used to treat bladder bowel problems like urinary retention. It is cholinergic agent that stimulates bladder to contract and urine to flow.
Mechanism of action (MOA)
Bethanechol is a muscarinic receptor that acts on the cholinergic receptors in smooth muscle of the gastrointestinal tract and urinary bladder. It increases the tone of the detrusor muscle in the urinary bladder producing an increase in intravesical pressure. It helps by emptying the bladder and relieves the micturition . It also initiates the gastric and intestinal motility and also raises the lower esophageal sphincter pressure.
Uses of Urecholine
1) Alleviates dry mouth
2) Treat urinary retention
3) Treat lack of muscular tone in gastrointestinal tract
4) Increase gastric motility
5) May treat cerebral palsy .
As it is a cholinergic receptor it mainly helps in relaxing the detrusor muscles in the urinary bladder and helps in urinary flow .
Dosage and Administration
It can be taken orally or subcutaneously.
Take this medicine empty stomach or 1 -2 hours after taking meals as it will help reduce nausea if you take it on empty stomach.
Dosage is based on your condition and as per doctors advice . But the adult dose is 25 to 50 mg three or four times a day.
Side-Effects of Urecholine
6) Abdominal cramps
7) Excess salivating
8) Profuse sweating
11) Shortness of breath
12) Tightness of chest
5) Frequent urge to urinate
6) Blurred vision
9) Stomach pain
10) Fall in blood pressure
12) Cardiac arrest
13) Bloody diarrhoea
14) Reflex tachycardia
16) Colicky pain
19) Bronchial constrictions
20) Miliaria crytallina
Precautions and Warning
Tell your doctor about any allergy you have. Also tell your doctor if you have any other disease like heart disease , kidney or lung disease like asthma or copd , peritonitis or parkinsonism or blockage of bladder . If you had any recent stomach /kidney/lung/intestine/knee surgery please tell your doctor about it .
Pregnancy and Breast-Feeding
Adequate studies have not been done to confirm the fact that Urecholine can be taken in pregnancy or not .Also no studies have been done in animals.
But if it is absolutely needed then only you can take it but not before discussing the effects with your doctor.
Also it has been seen that it gets mixed with the milk while nursing so please take care while nursing don’t take Urecholine or consult your doctor if necessary.
Please tell your doctor if you are using a high blood pressure medicine as these medications usually interfere with laboratory tests and gives false report. It has been seen that some drugs interact with the Urecholine and may change the course of dose. Please consult your doctor about the drugs you use.
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