Ziana is the brand name for a combination dug clindamycin and tretinoin. It is very commonly used for the treatment of acne. They are found in tubes that are stored in a temperature of 77 degrees F. There are certain side-effects resulting from its usage including redness, peeling, photosensitivity, dryness and itching. Sunlight must be avoided at the time of applying this medication as it may result in irritation. The best time suited for its application is in the evening or at the night.
Composition of Ziana
This medication contains a combination of two drugs that is a retinoid and an antibiotic. These two are the main active ingredients. There are many inactive ingredients along with the active ones. They are mentioned below:
- Tromethamine USP
- Butylated Hydroxytoluene NF
- Propylparaben NF
- Citric Acid USP
- Edetate Disodium USP
- Polysorbate 80 NF
- Methylparaben NF
- Carbomer 981 NF
- Glycerine USP
- Purified water USP
Uses of Ziana
This combination drug is used for treating acne. It helps in decreasing the severity as well as the number of acne pimples and also heals those pimples quickly that have already erupted. Tretinoin (from the class of medications called retinoids) affects the growth rate of skin cells. Clindamycin (an antibiotic) does not allow the growth of the bacteria that result in acne.
Side-effects of Ziana
There can be some side-effects resulting from the use of Ziana among different patients. The patient must take note of these side-effects which may result. Some of these are mentioned below:
- Unusually warm skin
- Redness or flushing of the skin
- Peeling and dryness of the skin
- Bloody or watery diarrhoea
- Tenderness, pain, or stomach cramps
- Changes in the skin colour
- Stinging or burning at the application site
- Unusual weakness or tiredness
- Wheezing or tightness in the chest
- Runny or stuffy nose
- Sore throat
- Troubled breathing or shortness of breath
- Tenderness or pain around the cheekbones and eyes
- Muscle aches
- Dry skin
Contraindications of Ziana
There are certain medical conditions under which the individual must not use this combination medication as it might be harmful for their body. These physical conditions are as follows:
- Allergic reaction to Lincosamides Vitamin A Analogues
- A mother who is breastfeeding or producing milk
- Atopic Dermatitis
- Clostridium Difficile Bacteria Related Colitis
- Ulcerated Colon
- Crohn’s Disease
Ziana and Pregnancy
Ziana was assigned to the pregnancy category C by the FDA. Though there have not been any well controlled experimentation on pregnant women who have been treated from Ziana gel, it should only be used if the potential risks to the foetus outweigh the benefits. In New Zealand, Ziana Gel was considered to be no observed adverse effect level (NOAEL) for developmental and maternal toxicity when tested on white rabbits with doses of the amount 60, 180, and 600 mg/kg/day.
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