A New Treatment Can Relieve Childhood Eczema and Asthma
A new research study has been able to find a new approach for the treatment of atopic eczema along with the prevention of the worsening of asthma occurring in children. The study was published in a journal named Journal of Investigative Dermatology.
Atopic dermatitis, also called eczema, is known to affect about 15 percent or 20 percent of children and about 1 to 3 percent of adults all over the world.
In the United States, about 10 to 20 percent of the children who are under the age of 10 years suffer from atopic eczema which accounts for about 28 million American children.
The condition is quite common in children. Some infants who are affected by this condition may develop asthma or allergic rhinitis after they grow up. This is considered as “atopic march”, a phenomenon whose mechanism and causes have made researchers quite confused in the past few years.
A new study has been able to shed light in understanding the mechanism behind atopic march when researchers belonging to the VIB Ghent University located in Flanders, Belgium were looking forward to treat atopic dermatitis and asthma.
The research team was led by Prof. Karolien De Bosscher, Prof. Hamida Hammad, and Dr. Julie Deckers.
Study of Atopic March in Rodents
Dr. Deckers along with the team formulated a mouse model for atopic march where the rats were presented to house dust mites repeatedly through the lugs and skin. House dust mites are known for triggering asthma and eczema.
The researchers were curious to know if providing relief for skin inflammation with the help of PPAR [gamma] agonists and glucocorticoids have any role in influencing asthma development.
PPAR gamma agonists and glucocorticoids are considered to be two anti-inflammatory compounds that were administered to the mice topically.
The study was able to reveal insights regarding the complex way atopic march develops. As predicted by the lead researcher, the test was able to show that house dust mite-induced skin swelling can lead to allergic airway inflammation.
Dr. Deckers mentioned that to the researchers’ surprise, the airway inflammation response is quite different from the reaction given when the lungs are directly exposed to house dust mites without having skin inflammation in prior. These results have provided a deeper understanding regarding the complexity possessed by the atopic march, according to the lead researcher.
Childhood Eczema and Its ‘Potent Remedy’
With respect to the effect possessed by the combined anti-inflammatory compounds in the two conditions, the results were to be successful.
The authors mentioned that cutanoeus combined activation of PPAR gamma agonists and glucocorticoids in reducing skin inflammation to a larger extent can be compared only to a single activation.
The combined therapy was helpful in alleviating atopic dermatitis, but was not capable of preventing the allergic asthma response observed in the lungs, according to Dr. Deckers.
In the near future, scientists want to publish results based on human clinical trials and work simultaneously on new therapies for stopping the worsening of atopic march.
Health Information Articles
- A Popular Prostate Drug Could Lead to Serious Side Effects
- HeartBurn Medicines and Risk of Deaths
- Deep Brain Simulations And Higher Survival Rate For Parkinson's Disease Patients
- A New Treatment Can Relieve Childhood Eczema and Asthma
- Asthma Drug Could Be a Potential Drug for Treating Aortic Aneurysm
- Ankylosing Spondylitis
- Parkinson`S Effect On The Gut
- Hepatitis B
- Optimize Cholesterol Level
- Lump Isn’t Always the First Sign of Breast Cancer
- Calcium And Vitamin D Supplements Do Not Help In Lowering Risk Of Bone Fracture
- A Simple Molecule Can Help in Overcoming Pre-Diabetes
- Bone Repair Process Trigger Through Nanophenomenon
- Blood Sodium Levels Impacts Cognition in Late Adulthood
- Cervical Spondylosis
- Enzyme’s Role in Burning Calories during Dieting and Obesity
- Calcium Pills May Facilitate Artery Build-up
- Benign Fasciculation Syndrome And Causes
- Certain Genes Can Help Bladder Cancer And Its Treatment
- Botox Injections Could Help With Migraine Pain in Children and Adolescents
- Supervised Injection Facilities to Help In Reducing Overdose Deaths
- Study Suggest There is a Role of Vitamin D3 to Heal or Prevent Cardiovascular Injuries
- Virus Ebola
- Antiemetic Drugs - Types and Side Effects
- Drugs To Reduce Harmfully Fat Cells
- Diabetic Foot Ulcers and Its Impact
- Have We Invited Our Suffering?
- According To Scientists, The Flavours Of E-Cigarette Are Toxic To The White Blood Cells
- Birth Control Pills Enhance the Risk of Breast Cancer
- Commonly Used Heartburn Medications Liked to Kidney Trouble
- Better Anti-Thrombotic Medication Target Identified
- Antioxidants Might Not Curb Dementia
- Does Asthma Have A Cure?
- New Drug Could Help In Fighting TB
- How to ease the Side Effects of ADHD Drugs in Adults
- Association Between Five Vascular Diseases And A Common Single Genetic Variant
- Melanoma Survival And Impact Of Existing Drugs
- Home Remedies for Hemorrhoids!
- Atrial Fibrillation
- Prevention of Osteopenia!