Amaryl is a medication that is primarily used to treat type 2 diabetes. It belongs to a class of drugs called sulfonylureas, which work by stimulating the release of insulin from the pancreas. Insulin is a hormone that helps regulate blood sugar levels in the body.

Drug Name: Amaryl

Active Ingredient: Glimepiride

Amaryl tablets



Form: Tablet

Type: Generic

Prescription Required: Rx

Availability: In Stock

Amaryl (generic name glimepiride) helps lower blood sugar levels by increasing the insulin production and release from the pancreas, as well as by improving the sensitivity of the body's cells to insulin. This helps the body utilize glucose more effectively and maintain appropriate blood sugar levels.

Amaryl is typically prescribed along with a proper diet and exercise program to control blood sugar in people with type 2 diabetes. It is not used to treat type 1 diabetes, as individuals with type 1 diabetes have little to no insulin production.

How to use

Here are general instructions on how to use Amaryl:

  1. Timing: Take tablets at the same time each day to establish a routine. This helps ensure consistent blood sugar control.
  2. Swallowing: Swallow the Amaryl tablet whole with a glass of water. Do not crush, chew, or break the tablet.
  3. Food and diet: Medicament is usually taken with a meal to coincide with the body's natural insulin release stimulated by food.
  4. Monitoring: Regularly monitor your blood sugar levels. This may involve using a glucose meter or other monitoring devices. Keep a record of your readings and discuss them with your healthcare provider during follow-up visits.
  5. Compliance: Take Amaryl consistently and do not miss doses. If you accidentally miss a dose, take it as soon as you remember, unless it's close to the time of your next dose. In that case, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Remember, these instructions are general guidelines, and it's crucial to consult your healthcare provider for personalized advice and guidance on using Amaryl. They will consider your specific medical needs and adjust the treatment accordingly.


The dosage of Amaryl can vary depending on several factors, including your individual condition, blood sugar levels, response to treatment, and other medications you may be taking. The following dosage information is a general guideline, but it may not be suitable for everyone:

  1. Starting dose: The typical initial dose of Amaryl for adults is 1 to 2 milligrams (mg) taken once daily with breakfast or the first main meal of the day.
  2. Maintenance dose: The maintenance dose is the dose that effectively controls your blood sugar levels while minimizing the risk of side effects. It may range from 1 to 4 mg once daily.
  3. Maximum dose: In some cases, your doctor may increase the dosage gradually up to a maximum of 8 mg per day, depending on your blood sugar control and individual requirements.
  4. Elderly patients: Older adults may have different dosing requirements due to age-related factors.
  5. Kidney or liver impairment: These organs play a role in metabolizing and eliminating the medication from your body, so dose adjustments may be necessary to ensure your safety and optimal effectiveness.

If you have any concerns or questions about your Amaryl dosage or experience any side effects, contact your healthcare provider for guidance. They have the necessary knowledge of your medical history and can provide personalized advice based on your specific needs.

Side effects

Here are some common side effects associated with Amaryl:

  1. Hypoglycemia (low blood sugar): The most common side effect of Amaryl is hypoglycemia, especially if the medication lowers your blood sugar excessively. Symptoms of hypoglycemia may include dizziness, shakiness, sweating, hunger, headache, blurred vision, difficulty concentrating, or feeling irritable. It's important to be familiar with the signs of low blood sugar and to treat it promptly by consuming a source of glucose, such as fruit juice or glucose tablets. Severe hypoglycemia may require emergency medical attention.
  2. Gastrointestinal effects: Glimepiride can occasionally cause gastrointestinal disturbances, including nausea, vomiting, stomach discomfort, and diarrhea. These symptoms are usually mild and transient.
  3. Allergic reactions: In rare cases, Amaryl can cause allergic reactions. Seek immediate medical attention if you experience symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.
  4. Skin reactions: Some individuals may develop skin reactions while taking Amaryl, such as itching, redness, or a rash.
  5. Weight gain: Medicine may contribute to weight gain in some individuals. It is important to maintain a healthy lifestyle, including a balanced diet and regular exercise, to manage weight effectively.
  6. Liver function abnormalities: Amaryl, like other medications in its class, may rarely affect liver function.

These are not all possible side effects of Amaryl. Some individuals may experience other side effects not listed here.


To ensure the stability and effectiveness of Amaryl, it is important to store it properly. Here are general guidelines for storing:

  1. Temperature: Store medicine at room temperature, typically between 68°F (20°C) and 77°F (25°C).
  2. Avoid extreme temperatures: Keep the medication away from excessive heat or cold. Do not store it in direct sunlight, near radiators, or in the freezer.
  3. Moisture: Protect Amaryl from moisture by storing it in a tightly closed container. Avoid storing it in the bathroom, where humidity levels are higher.
  4. Keep out of reach of children and pets: Store Amaryl in a secure location out of the reach of children and pets to prevent accidental ingestion.
  5. Follow packaging instructions: Always refer to the specific storage instructions provided on the packaging or label of your Amaryl medication. Some formulations may have specific storage requirements.
  6. Do not use expired medication: Check the expiration date on the packaging and do not use Amaryl if it has expired. Expired medication may lose its effectiveness or become less safe to use.
  7. Proper disposal: Do not dispose of medications in the trash or flush them down the toilet unless specifically instructed to do so.

Proper storage helps maintain the integrity and effectiveness of the medication, ensuring that it remains safe to use.


An overdose of Amaryl can be serious and potentially life-threatening. It is essential to seek immediate medical attention or contact your local emergency services if you suspect an overdose. Here's some information regarding overdose:

  1. Signs and symptoms: An overdose of Amaryl can lead to hypoglycemia (low blood sugar). Symptoms of hypoglycemia may include dizziness, shakiness, sweating, confusion, blurred vision, rapid heartbeat, fainting, or seizures. If left untreated, severe hypoglycemia can result in coma or even death.
  2. Prompt action: If you or someone else has taken more Amaryl than prescribed, it's crucial to act quickly. Call emergency services or go to the nearest emergency room for immediate medical assistance.
  3. Provide information: When seeking medical help, be sure to provide information about the medication and the amount taken.
  4. Treatment: Treatment for an Amaryl overdose typically involves addressing and stabilizing blood sugar levels. This may include providing intravenous (IV) glucose or administering glucagon to raise blood sugar rapidly.
  5. Avoiding future overdoses: It is important to take Amaryl strictly as prescribed by your doctor and to follow the recommended dosage and instructions. Regular monitoring of blood sugar levels.

Remember, an Amaryl overdose can have serious consequences, and prompt medical attention is crucial. If you suspect an overdose or experience severe hypoglycemic symptoms, seek immediate medical assistance or contact your local emergency services.

Missed Doses

If you accidentally miss a dose of Amaryl, follow these general guidelines:

  1. Take it as soon as you remember: If you realize that you have missed a dose and it is not too close to the time of your next scheduled dose, take the missed dose as soon as you remember. This helps ensure that you maintain consistent blood sugar control.
  2. Skip the missed dose if it's close to the next dose: If it is almost time for your next scheduled dose, it is advisable to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
  3. Do not take extra doses: Taking extra doses of Amaryl to compensate for missed doses can increase the risk of hypoglycemia (low blood sugar). It is important to follow the prescribed dosage and not exceed it.

top page