Combipres is a medication that combines two active ingredients: clonidine and chlorthalidone. It is used to treat high blood pressure (hypertension). Clonidine is a centrally acting alpha-2 adrenergic agonist that helps lower blood pressure by reducing the nerve signals sent to blood vessels, resulting in relaxation and widening of the vessels. Chlorthalidone is a diuretic that helps remove excess fluid from the body, thereby reducing the volume of blood and lowering blood pressure.

Drug Name: Combipres

Active Ingredient: Clonidine

Combipres tablets



Form: Tablet

Type: Generic

Prescription Required: Rx

Availability: In Stock

Combipres is prescribed for individuals with high blood pressure that is not adequately controlled by a single medication. By combining clonidine and chlorthalidone, it addresses both the underlying mechanisms of high blood pressure, namely the narrowing of blood vessels and fluid retention.

How to use

Here are some general guidelines for using Combipres:

  1. Timing: Medicine is usually taken once or twice a day, depending on the prescribed dosage.
  2. Administration: Take Combipres orally with a full glass of water. You can take it with or without food, but try to be consistent in taking it the same way each time.
  3. Swallowing the Tablets: Swallow the tablets whole. Do not crush, chew, or break them.
  4. Compliance: Take Combipres regularly and consistently to achieve the best results. Missing doses or stopping the medication abruptly can negatively impact its effectiveness.
  5. Follow-Up Appointments: It is important to keep track of your blood pressure readings.


Here are some general dosage guidelines for Combipres:

  1. Initial Dosage: The starting dose of Combipres may vary depending on the severity of your high blood pressure.
  2. Titration: In most cases, the dosage of Combipres is gradually increased to achieve optimal blood pressure control.
  3. Maintenance Dosage: Once the desired blood pressure control is achieved, your doctor will prescribe a maintenance dosage that is suitable for you. This dosage aims to maintain your blood pressure within the target range.
  4. Combination Tablet: Drug is available in various strengths that contain different amounts of clonidine and chlorthalidone.
  5. Individualized Treatment: The dosage and treatment duration of Clonidine will depend on your specific condition, medical history, and response to the medication.

Side effects

Combipres may cause certain side effects in some individuals. While not everyone experiences these side effects, it is important to be aware of them. Common side effects may include:

  1. Dizziness or lightheadedness: Some individuals may experience dizziness or a feeling of lightheadedness, especially when standing up quickly from a sitting or lying position. Taking precautions such as getting up slowly can help minimize these effects.
  2. Dry mouth: Combipres may cause a dry sensation in the mouth. Drinking plenty of water, chewing sugarless gum, or using saliva substitutes can help alleviate this symptom.
  3. Fatigue or drowsiness: Medicament may cause fatigue or drowsiness in some individuals. It is important to avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
  4. Constipation: Chlorthalidone, one of the components of Combipres, is a diuretic that can sometimes lead to constipation. Ensuring adequate fluid intake and consuming a fiber-rich diet can help alleviate this symptom.
  5. Nausea or upset stomach: Some individuals may experience nausea or an upset stomach when taking Combipres. Taking the medication with food can help reduce these side effects.
  6. Sexual dysfunction: In some cases, Clonidine may cause sexual dysfunction, including decreased libido or difficulty achieving or maintaining an erection.
  7. Other side effects: Less commonly, Combipres may cause other side effects such as headaches, blurred vision, skin rash, or swelling in the feet or hands.


When it comes to storing Combipres, it is important to follow proper storage guidelines to maintain the medication's effectiveness and ensure its safety. Here are some recommendations for storing:

  1. Temperature: Store medicine at room temperature, typically between 68°F (20°C) and 77°F (25°C).
  2. Avoid Moisture: Keep the medication in a dry place. Avoid storing it in the bathroom, where moisture and humidity levels are higher.
  3. Light Exposure: Protect Combipres from excessive light exposure. Store the medication in its original packaging, which is designed to shield it from light.
  4. Keep Away from Children and Pets: Store tablets in a secure location out of the reach of children and pets. The medication should only be used by the individual it is prescribed for.
  5. Follow Packaging Instructions: Follow any specific storage instructions provided on the Combipres packaging.
  6. Do Not Transfer: Avoid transferring Combipres to another container unless instructed to do so. Keep the medication in its original packaging, complete with proper labeling.
  7. Check Expiry Date: Before using Combipres, check the expiration date on the packaging. Do not use the medication if it has expired. Properly dispose of any expired or unused medication.


An overdose of Clonidine can have serious consequences and should be treated as a medical emergency. If you suspect an overdose or have taken more than the prescribed amount of Combipres, it is important to seek immediate medical attention by calling your local emergency services or contacting a poison control center.

Overdosing on Combipres can lead to excessive lowering of blood pressure, which may cause symptoms such as:

  1. Severe dizziness or lightheadedness
  2. Fainting or loss of consciousness
  3. Slow or irregular heartbeat
  4. Difficulty breathing
  5. Extreme fatigue or weakness
  6. Confusion or disorientation
  7. Bluish discoloration of the skin or lips

It is crucial to provide emergency medical professionals with accurate information regarding the medication you have taken and the dosage. If possible, have the Combipres packaging or prescription details available.

While waiting for medical assistance, if the person is conscious and able to communicate, encourage them to stay calm and lie down. Do not induce vomiting.

Remember, it is important to act quickly in the case of a Combipres overdose to ensure prompt medical intervention and minimize potential complications.

Missed Doses

If you miss a dose of Combipres, it is important to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

Here are some additional guidelines for managing missed doses of Combipres:

  1. Set Reminders: To help you remember to take your medication, consider setting alarms or reminders on your phone or using pill organizers.
  2. Consistency: Try to take Combipres at the same time(s) each day to maintain a consistent medication routine.
  3. Do Not Double Dose: It is important not to double dose to make up for a missed dose. Taking more medication than prescribed can increase the risk of side effects and complications.

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