Estrace is a medication that contains estradiol, which is a form of estrogen hormone. It is used to treat various conditions associated with estrogen deficiency in the body. Estradiol is a natural hormone produced by the ovaries in females, and it plays a crucial role in the development and maintenance of female reproductive tissues.

Drug Name: Estrace

Active Ingredient: Estradiol

Estrace tablets



Form: Tablet

Type: Generic

Prescription Required: Rx

Availability: In Stock

Here are some key points about Estrace:

  1. Estrogen replacement therapy: Estrace is commonly prescribed as a hormone replacement therapy (HRT) for women who are experiencing symptoms of menopause or have undergone surgical removal of the ovaries. It helps alleviate menopausal symptoms such as hot flashes, vaginal dryness, and night sweats.
  2. Hormone imbalance: Estradiol may also be prescribed to treat certain hormonal imbalances, such as low estrogen levels or conditions that require estrogen supplementation, including primary ovarian failure or certain types of breast cancer.
  3. Route of administration: Medicine is available in different formulations, including oral tablets, transdermal patches, and vaginal creams. The specific formulation and dosage will depend on the individual's medical condition.
  4. Estrogen risks and benefits: Estrogen therapy, including Estrace, may have both benefits and risks.
  5. Monitoring and follow-up: While using Estrace or any estrogen therapy, regular check-ups and monitoring may be necessary.
  6. Precautions and contraindications: Estrace is not suitable for everyone. It is contraindicated in individuals with a history of estrogen-dependent cancer, blood clots, liver disease, or certain other medical conditions.

How to use

Here are some general guidelines on how to use Estrace:

  1. Formulations: Estrace is available in various formulations, including oral tablets, transdermal patches, and vaginal creams. The specific formulation prescribed to you will determine the method of administration.
  2. Oral tablets: If you are prescribed tablets, take them orally. Swallow the tablet whole with water, with or without food, according to the prescribed dosage and schedule. Follow the specific instructions regarding timing and frequency of administration.
  3. Transdermal patches: If you are using Estrace transdermal patches, apply the patch to a clean, dry, and intact area of skin, usually on the lower abdomen or buttocks. Follow the instructions on the patch package regarding application technique, frequency of patch changes, and duration of use. Rotate the application site to minimize skin irritation.
  4. Vaginal cream: If you are using Estrace vaginal cream, follow the instructions provided with the cream. Typically, a prescribed amount of cream is inserted into the vagina using the applicator provided. The applicator should be thoroughly cleaned before and after each use.
  5. Compliance: Take Estradiol exactly as prescribed. It is important to follow the prescribed dosage, schedule, and duration of treatment to ensure the best outcomes.


The dosage of Estrace will vary depending on the specific condition being treated, the formulation of Estradiol prescribed, and individual factors such as age, medical history, and response to treatment. Here are some general guidelines on dosage for different formulations:

  1. Oral tablets: For the treatment of menopausal symptoms or estrogen deficiency, the typical starting dosage of oral tablets is 0.5 to 2 milligrams (mg) once daily. The dosage may be adjusted based on individual response and the severity of symptoms.
  2. Transdermal patches: The dosage of Estrace transdermal patches is usually expressed in terms of the amount of estradiol delivered per day. Common dosage ranges for transdermal patches are between 0.025 to 0.1 mg estradiol per day.
  3. Vaginal cream: The dosage of Estradiol vaginal cream is typically prescribed in terms of the number of grams to be applied intravaginally. Common dosages range from 2 to 4 grams of cream per day for a certain period of time.

Side effects

Estrace may cause side effects in some individuals. It's important to note that not everyone will experience these side effects, and their severity can vary. Here are some common side effects:

  1. Nausea: Some individuals may experience a feeling of nausea after taking Estrace. Taking the medication with food or adjusting the dosage timing may help alleviate this symptom.
  2. Headache: Headaches, including migraines, can occur as a side effect of Estrace.
  3. Breast tenderness: Estradiol may cause breast tenderness or discomfort. This side effect is usually mild and temporary.
  4. Irregular vaginal bleeding: Estrogen therapy can cause irregular vaginal bleeding, especially during the initial months of treatment.
  5. Fluid retention: Some individuals may notice mild fluid retention, resulting in bloating or swelling in the extremities.
  6. Mood changes: Estrogen therapy can affect mood and emotions. While some individuals may experience an improvement in mood, others may notice changes such as mood swings, irritability, or depression.
  7. Skin reactions: Rarely, Estrace can cause skin reactions such as rash or itching. If you develop a skin reaction after using Estrace, seek medical attention.
  8. Blood clots: Estrogen therapy may increase the risk of blood clots, including deep vein thrombosis (DVT) or pulmonary embolism. Seek immediate medical attention if you experience symptoms such as leg pain, swelling, chest pain, or shortness of breath.


Here are some general guidelines for storing Estrace:

  1. Temperature: Store Estrace at room temperature, ideally between 68°F (20°C) and 77°F (25°C). Avoid exposing the medication to excessive heat or cold, as it may affect its effectiveness.
  2. Moisture: Keep the medication away from moisture, including high humidity or damp areas. Avoid storing Estrace in the bathroom, where moisture levels are typically higher.
  3. Light: Protect Medicine from direct sunlight and prolonged exposure to light. Store it in a dark place or in its original packaging, which is designed to shield the medication from light.
  4. Childproof container: Ensure that the Estrace medication is stored in a childproof container or in a secure location out of reach of children and pets. This helps prevent accidental ingestion or misuse.
  5. Proper packaging: If you are using Estradiol in the form of transdermal patches or vaginal cream, ensure that the patches or tubes are properly sealed and stored according to the instructions provided. Follow any specific storage recommendations for these formulations.


If you suspect an overdose of Estradiol, it is important to seek immediate medical attention or contact your local poison control center. Overdose can occur if you accidentally take more than the prescribed dose of Estrace. Here are some general guidelines on what to do in case of an overdose:

  1. Contact emergency services: If you or someone else may have taken an excessive amount of Estrace, call emergency services right away. Provide them with all the necessary information and follow their instructions.
  2. Symptoms: Overdose symptoms may vary depending on the individual, the amount ingested, and other factors. Symptoms of an Estradiol overdose may include nausea, vomiting, breast tenderness, vaginal bleeding, dizziness, or drowsiness. However, it is important to note that an overdose of estradiol may have serious effects, and medical professionals should evaluate the situation.

It's crucial to remember that the information provided here is a general guideline. In case of an overdose, immediate medical attention is necessary.

Missed Doses

If you miss a dose of Estrace, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Here are some additional guidelines regarding missed doses of Estrace:

  1. Timing: Try to take the missed dose as soon as you remember. However, if it is already time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule.
  2. Do not double the dose: Do not take a double dose to make up for a missed one. Taking more than the prescribed dose can increase the risk of side effects and may not provide any additional benefits.
  3. Set reminders: To help remember taking your medication, consider setting reminders such as alarms or using pill organizers. This can help ensure that you take Estrace consistently and at the appropriate times.

It's important to maintain a regular dosing schedule for Estrace to achieve optimal results.

top page