Hyzaar is a medication that contains a combination of two active ingredients: losartan potassium and hydrochlorothiazide. It is primarily used to treat high blood pressure (hypertension).

Drug Name: Hyzaar

Active Ingredient: Losartan/Hydrochlorothiazide

Hyzaar tablets



Form: Tablet

Type: Generic

Prescription Required: Rx

Availability: In Stock

Losartan potassium belongs to a class of medications called angiotensin II receptor blockers (ARBs). It works by blocking the action of a hormone called angiotensin II, which constricts blood vessels and causes blood pressure to rise. By blocking the effects of angiotensin II, losartan helps relax and widen the blood vessels, thereby reducing blood pressure.

Hydrochlorothiazide is a diuretic, commonly known as a "water pill." It helps the body eliminate excess water and salt through increased urine production. By reducing fluid volume, hydrochlorothiazide also helps lower blood pressure.

The combination of losartan potassium and hydrochlorothiazide in Hyzaar allows for a more comprehensive approach to managing hypertension. By targeting both blood vessel constriction and fluid volume, it can be more effective in lowering blood pressure than either medication alone.

Medicine is available in tablet form and is typically taken orally once a day, with or without food. The dosage may vary depending on the specific needs of the individual. It is important to follow the prescribed dosage and continue taking Hyzaar as directed, even if you feel well, to effectively manage your blood pressure.

How to use

Here are some general guidelines for using Hyzaar:

  1. Follow the dosing schedule: Hyzaar is typically taken once a day. It can be taken with or without food, but try to take it around the same time each day to help establish a routine.
  2. Swallow the tablet whole: Take the tablet with a glass of water.
  3. Keep up with regular appointments: Attend regular check-ups to monitor your blood pressure and overall health. They may need to adjust your dosage or make other recommendations based on your progress.
  4. Do not miss doses: If you forget to take a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
  5. Be cautious with other medications: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as they may interact with Hyzaar. Certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), may affect the effectiveness of Hyzaar or increase the risk of side effects.
  6. Follow lifestyle recommendations: Along with taking Hyzaar, follow any lifestyle changes to help manage your blood pressure. This may include adopting a healthy diet, regular exercise, limiting alcohol consumption, and quitting smoking if applicable.


The typical recommended starting dosage for Hyzaar is one tablet once daily.

The strength of Hyzaar tablets may vary, and the most common strengths include 50 mg losartan potassium and 12.5 mg or 25 mg hydrochlorothiazide.

Side effects

Hyzaar may cause certain side effects in some individuals. Not everyone will experience these side effects, and their severity can vary. Here are some common side effects:

  1. Dizziness or lightheadedness: Medicine can cause a drop in blood pressure, leading to dizziness or lightheadedness. It is important to get up slowly from a sitting or lying position to minimize this effect.
  2. Fatigue or tiredness: Some individuals may experience fatigue or a general feeling of tiredness while taking Hyzaar.
  3. Headache: Headaches can occur as a side effect of this drug.
  4. Increased urination: The hydrochlorothiazide component of Hyzaar can increase urine production, leading to more frequent urination.
  5. Muscle cramps: Some people may experience muscle cramps while taking Hyzaar.
  6. Nausea or vomiting: In some cases, Hyzaar may cause gastrointestinal symptoms such as nausea or vomiting.
  7. Back pain: Back pain has been reported as a potential side effect of Hyzaar.
  8. Allergic reactions: Although rare, some individuals may experience allergic reactions to Hyzaar, characterized by symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.


Hyzaar should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. Here are some specific storage instructions:

  1. Temperature: Keep tablets at a temperature between 68°F (20°C) and 77°F (25°C).
  2. Moisture: Store the medication in a tightly closed container to protect it from moisture. Avoid storing it in the bathroom or any area with high humidity.
  3. Light: Protect Medicine from direct sunlight. Keep it in a dark place, such as a closed cabinet or drawer.
  4. Keep out of reach: Store Hyzaar out of the reach of children and pets, as it is important to prevent accidental ingestion.
  5. Do not transfer: Keep the medication in its original packaging or container. Avoid transferring the tablets to other containers, as this can lead to confusion or accidental misuse.


An overdose of Hyzaar can be serious and may require immediate medical attention. If you suspect an overdose or if someone has accidentally taken more than the prescribed dose of Hyzaar, it is important to seek medical help or contact your local poison control center right away. Here are some possible symptoms and steps to take in case of an overdose:

  1. Symptoms of overdose: Signs of an overdose may include excessive dizziness, lightheadedness, fainting, rapid or irregular heartbeat, severe drowsiness, confusion, electrolyte imbalances, extremely low blood pressure, or kidney problems.
  2. Seek medical assistance: Call emergency services or go to the nearest emergency room immediately. It is important to provide them with information about the medication taken, including the name, strength, and amount ingested.
  3. Supportive care: In the case of an overdose, supportive care will be provided to manage symptoms and stabilize the individual's condition. This may include measures to maintain blood pressure, support heart function, monitor electrolyte levels, and provide appropriate medical treatment.

Missed Doses

If you miss a dose of Hyzaar, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

It is important to try and take Hyzaar at the same time each day to maintain a consistent level of medication in your body. If you frequently forget to take your doses, consider setting a reminder alarm or using a pill organizer to help you remember.

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