Isosorbide Mononitrate

Isosorbide Mononitrate

Isosorbide mononitrate is a medication that belongs to a class of drugs called nitrates. It is used to prevent and treat angina pectoris, a condition characterized by chest pain or discomfort caused by a lack of oxygen supply to the heart muscle. Isosorbide mononitrate works by relaxing and widening the blood vessels, allowing for improved blood flow to the heart.

Drug Name: Monoket

Active Ingredient: Isosorbide Mononitrate

Isosorbide Mononitrate tablets



Form: Tablet

Type: Generic

Prescription Required: Rx

Availability: In Stock

This medication is commonly prescribed to individuals with coronary artery disease, which is a narrowing or blockage of the blood vessels that supply oxygen to the heart. Medicine helps relieve angina symptoms such as chest pain, pressure, or tightness, and reduces the frequency and severity of angina episodes.

Isosorbide mononitrate is typically taken orally in the form of extended-release tablets, which release the medication slowly over time.

How to use

Here are some general guidelines for using Isosorbide mononitrate:

  1. Take as prescribed: Take medicine exactly as prescribed. Follow the recommended dosage, frequency, and duration of treatment. Do not take more or less of the medication.
  2. Swallow whole: Swallow the extended-release tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as it is designed to release the medication slowly over time.
  3. Take on an empty stomach: It is generally recommended to take Isosorbide mononitrate on an empty stomach, at least one hour before or two hours after a meal.
  4. Stick to a consistent schedule: Take Isosorbide mononitrate at the same time each day to maintain a steady level of the medication in your body. This can help ensure its effectiveness in preventing angina episodes.
  5. Do not stop abruptly: Do not stop taking drug suddenly, as it may lead to a worsening of angina symptoms.
  6. Avoid grapefruit juice: Grapefruit juice may interact with Isosorbide mononitrate and affect its absorption in the body. It is advisable to avoid consuming grapefruit juice while taking this medication.


The dosage of Isosorbide mononitrate will vary depending on your specific medical condition and needs. The information provided here is a general guideline:

  1. Starting dose: The usual starting dose for Isosorbide mononitrate extended-release tablets is typically 30 to 60 milligrams (mg) once daily in the morning.
  2. Titration: The dose may be increased gradually, typically at intervals of 3 to 5 days, to achieve optimal results. The maximum recommended daily dose is usually 120 mg.
  3. Swallow whole: Take the extended-release tablet whole, without crushing or chewing it. It should be swallowed with a full glass of water.
  4. Regular use: Medicine is usually taken once daily. It is important to take it at the same time each day to maintain a consistent level of the medication in your body.
  5. Do not exceed prescribed dose: Taking more than the recommended amount can increase the risk of side effects without providing additional benefit.

Side effects

Isosorbide mononitrate, like any medication, may cause side effects in some individuals. Not everyone who takes this medication will experience side effects, and the severity and occurrence of side effects can vary from person to person. Here are some possible side effects:

  1. Headache: One of the most common side effects of Isosorbide mononitrate is a headache. It may be mild to moderate in intensity and usually improves over time as your body adjusts to the medication.
  2. Flushing: Flushing, characterized by a warm or red sensation in the face and neck, is another common side effect. It is usually temporary and harmless.
  3. Low blood pressure: Isosorbide mononitrate can cause a drop in blood pressure, which may lead to symptoms such as dizziness, lightheadedness, or fainting. These symptoms are more likely to occur when standing up quickly. To minimize this effect, it is advisable to change positions slowly.
  4. Increased heart rate: Some individuals may experience an increase in heart rate while taking Isosorbide mononitrate. This is typically a mild and temporary effect.
  5. Gastrointestinal disturbances: Isosorbide mononitrate can occasionally cause gastrointestinal symptoms such as nausea, vomiting, or diarrhea. These side effects are generally mild and resolve on their own.
  6. Other side effects: Rarely, Isosorbide mononitrate may cause allergic reactions, including rash, itching, swelling, or difficulty breathing. If you experience any signs of an allergic reaction, seek immediate medical attention.


To ensure the effectiveness and safety of Isosorbide mononitrate, it is important to store it properly. Here are some guidelines for storing:

  1. Temperature: Store tablets at room temperature, ideally between 68°F (20°C) and 77°F (25°C).
  2. Moisture: Keep the medication away from excessive moisture and humidity. Avoid storing it in the bathroom, where moisture levels are high.
  3. Light: Protect drug from direct sunlight and strong artificial light. Store it in a dark place, such as a drawer or cabinet.
  4. Original packaging: Keep pills in its original packaging or container. This helps protect the medication from exposure to air, moisture, and light.
  5. Childproof container: If the medication comes in a childproof container, make sure to close it tightly and store it out of the reach of children.
  6. Avoid extreme conditions: Do not store tablets in extreme temperatures, such as in the freezer or near a heating source. Extreme temperatures can affect the stability and effectiveness of the medication.
  7. Proper disposal: If you have expired or unused Isosorbide mononitrate, consult your pharmacist or local waste disposal guidelines on how to dispose of it properly. Do not dispose of medications in the household trash or flush them down the toilet unless instructed to do so.

Always check the specific storage instructions on the medication packaging or consult your pharmacist if you have any doubts or questions about storing Isosorbide mononitrate. Following proper storage practices helps maintain the integrity of the medication and ensures its effectiveness when needed.


If you suspect an overdose or have taken more than the prescribed dose of Isosorbide mononitrate, take the following steps:

  1. Call emergency services: Dial emergency services or contact your local poison control center immediately. Inform them about the overdose and provide any necessary details they may require.
  2. Do not induce vomiting: Do not induce vomiting unless specifically instructed to do so by medical professionals. Vomiting may not effectively remove the medication from your system and can pose additional risks.
  3. Provide information: Provide accurate information about the dosage and timing of Isosorbide mononitrate ingestion.

Overdosing on Isosorbide mononitrate can lead to severe low blood pressure, which may result in symptoms such as fainting, dizziness, or rapid heartbeat. It is important to seek immediate medical attention to prevent complications and ensure appropriate management.

Missed Doses

If you miss a dose of Isosorbide mononitrate, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Here are some important points to keep in mind regarding missed doses of Isosorbide mononitrate:

  1. Timing: Try to take the missed dose as soon as you remember. If it is already time for your next scheduled dose, do not take an extra dose to catch up. Simply continue with your regular dosing schedule.
  2. Do not double dose: Taking a double dose to make up for a missed one can increase the risk of side effects without providing any additional benefit. Stick to the prescribed dosage and do not exceed it.
  3. Set reminders: To help remember taking your medication on time, you may find it helpful to set reminders, use pill organizers, or establish a routine that aligns with your dosing schedule.

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