Nexavar is the brand name for the medication Sorafenib. It is an oral chemotherapy drug that belongs to a class of medications called kinase inhibitors. Medicine is primarily used in the treatment of certain types of cancer, including liver cancer (hepatocellular carcinoma) and advanced renal cell carcinoma (a type of kidney cancer).

Drug Name: Nexavar

Active Ingredient: Sorafenib

Nexavar tablets



Form: Tablet

Type: Generic

Prescription Required: Rx

Availability: In Stock

Sorafenib works by inhibiting the activity of specific proteins involved in cancer cell growth and angiogenesis (the formation of new blood vessels that supply nutrients to tumors). By blocking these proteins, Nexavar helps to slow down or stop the growth and spread of cancer cells.

How to use

Here are some general guidelines for using Nexavar, but please note that your specific dosage and instructions may vary:

  1. Take Nexavar as prescribed: Do not take more or less of the medication than instructed.
  2. Take Sorafenib on an empty stomach or with a low-fat meal: Medicine should be taken at least one hour before or two hours after a meal. Swallow the tablets whole with a full glass of water.
  3. Stick to a consistent dosing schedule: Take Nexavar at the same time(s) each day to maintain consistent levels of the medication in your body. This will help ensure its effectiveness.
  4. Do not crush or chew tablets: Do not crush, chew, or break the tablets. Swallow them whole.
  5. Do not make dosage adjustments without medical advice: Do not adjust your Nexavar dosage. Any changes to your treatment plan should be made under their supervision.


The dosage of Nexavar can vary depending on the type of cancer being treated and individual patient factors. The information provided here is a general guideline, but it may not be applicable to everyone.

For the treatment of liver cancer (hepatocellular carcinoma), the typical starting dosage of Nexavar for adults is 400 mg (two 200 mg tablets) taken orally twice daily.

For the treatment of advanced renal cell carcinoma (kidney cancer), the usual recommended dosage of Nexavar for adults is 400 mg (two 200 mg tablets) taken orally twice daily.

Please note that these are general dosage recommendations and can vary depending on individual patient factors.

Side effects

Nexavar can cause side effects, although not everyone experiences them. It's important to note that the severity and occurrence of side effects may vary among individuals. Here are some common side effects:

  1. Fatigue: Feeling tired or weak is a common side effect of Nexavar. It is advisable to get plenty of rest and conserve energy during treatment.
  2. Diarrhea: Sorafenib can cause diarrhea, which may range from mild to severe.
  3. Nausea and vomiting: Some individuals may experience nausea and vomiting while taking Nexavar. Medications or lifestyle changes can help manage these symptoms.
  4. Hand-foot skin reaction: Medicine may cause a skin reaction on the palms of the hands and soles of the feet. This can present as redness, tenderness, blistering, peeling, or a rash.
  5. Hypertension (high blood pressure): Nexavar can increase blood pressure in some individuals. Regular monitoring of blood pressure and appropriate management is essential.
  6. Loss of appetite: Some people may experience a decreased appetite or weight loss while taking this drug.
  7. Hair changes: Nexavar may cause changes in hair color or texture. These changes are usually temporary and reversible after stopping treatment.
  8. Increased risk of bleeding: Medicament may increase the risk of bleeding.
  9. Muscle or joint pain: Some individuals may experience muscle or joint pain while taking Nexavar.
  10. Changes in liver function: Nexavar can affect liver function, leading to changes in liver enzyme levels. Regular monitoring of liver function is important during treatment.


To properly store Nexavar, please follow these guidelines:

  1. Keep in a cool, dry place: Store tablets at room temperature, away from excessive heat, moisture, and direct sunlight. Avoid storing it in the bathroom or near the kitchen sink where it may be exposed to humidity.
  2. Follow packaging instructions: Store Sorafenib in its original packaging or container, following any specific storage instructions provided by the manufacturer or pharmacist.
  3. Keep out of reach of children and pets: Store medicine in a secure location, out of sight and reach of children and pets. The medication should only be accessed and used by the intended individual under proper supervision.
  4. Protect from moisture: Ensure the packaging is tightly closed to protect the medication from moisture. If you are using a blister pack or individual foil packets, only open them when you are ready to take the medication.
  5. Do not transfer to different containers: It is recommended to keep Nexavar in its original packaging or container. Do not transfer the tablets to different containers.
  6. Check expiration date: Regularly check the expiration date on the packaging. Expired medication should not be used, and proper disposal methods should be followed.

It's important to note that these storage guidelines are general recommendations. Always refer to the specific instructions provided with your medication or consult your pharmacist if you have any doubts or concerns regarding the proper storage of Nexavar. Following proper storage practices helps ensure the medication's effectiveness and maintains its quality.


An overdose of Sorafenib can be serious and potentially life-threatening. If you suspect an overdose or have taken more Nexavar than prescribed, it is crucial to seek immediate medical attention. Here's what you should do:

  1. Contact emergency services or go to the nearest emergency room: Call your local emergency services or proceed to the emergency room right away. Inform them that you have taken an overdose of Nexavar.
  2. Do not induce vomiting: Vomiting may not effectively remove the medication from your system and can potentially lead to additional complications.
  3. Supportive care: Depending on the severity of the overdose, supportive care may be provided to manage symptoms and monitor vital signs. This may include measures to maintain hydration, monitoring of liver and kidney function, and addressing any complications that may arise.

It is vital to remember that an overdose of Nexavar can have serious consequences, and immediate medical attention is necessary. If you or someone you know experiences an overdose, do not delay in seeking emergency medical help.

Missed Doses

If you miss a dose of Nexavar, here are some general guidelines to follow:

  1. Take the missed dose as soon as you remember: If you realize you have missed a dose and it is within a few hours of the scheduled time, take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
  2. Do not double the dose: Do not take a double dose of Nexavar to make up for the missed one. Taking more than the prescribed amount can increase the risk of side effects without providing additional benefit.
  3. Resume the regular dosing schedule: After taking the missed dose or skipping it, continue taking Nexavar as prescribed. It is important to maintain a consistent dosing schedule for the medication to be effective in managing your condition.

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