Nolvadex is the brand name for the medication tamoxifen citrate. It is a prescription drug that belongs to a class of medications called selective estrogen receptor modulators (SERMs). Medicine is primarily used in the treatment and prevention of breast cancer, particularly in individuals with hormone receptor-positive breast cancer.

Drug Name: Nolvadex

Active Ingredient: Tamoxifen

Nolvadex tablets



Form: Tablet

Type: Generic

Prescription Required: Rx

Availability: In Stock

Here are some key points about Nolvadex:

  1. Mechanism of action: Tamoxifen works by blocking the effects of estrogen in the breast tissue. It binds to estrogen receptors, preventing estrogen from binding and stimulating the growth of breast cancer cells.
  2. Treatment of breast cancer: Nolvadex is commonly used as an adjuvant therapy after surgery and other treatments for early-stage breast cancer to reduce the risk of cancer recurrence. It may also be used in the treatment of advanced or metastatic breast cancer.
  3. Prevention of breast cancer: Drug is approved for the prevention of breast cancer in women at high risk, particularly those with a family history of breast cancer or certain genetic mutations. It can reduce the risk of developing breast cancer in both pre- and postmenopausal women.
  4. Off-label uses: Medicine may also be used in the treatment of certain types of infertility, gynecomastia (enlarged breasts) in men, and as a part of hormone replacement therapy in select cases.
  5. Administration: Nolvadex is available in tablet form and is typically taken orally once or twice daily. The dosage and duration of treatment will depend on the specific condition being treated and individual factors.
  6. Monitoring and precautions: Regular check-ups, including breast exams and gynecologic examinations, are important while taking Nolvadex.

How to use

Here are some general guidelines for using Nolvadex:

  1. Read the medication guide: Carefully read the patient information leaflet or medication guide provided with Nolvadex. It contains important information about the medication, including dosage instructions, precautions, and possible side effects.
  2. Follow the prescribed dosage: Take Nolvadex exactly as prescribed. Do not take more or less than the recommended dose, and do not alter the dosing schedule.
  3. Take with or without food: Medicine can be taken with or without food. If you experience stomach upset, taking it with food may help alleviate this side effect.
  4. Swallow the tablets whole: Take the tablets with a glass of water. Do not crush, chew, or break the tablets before swallowing, as this may affect the medication's effectiveness.
  5. Stick to a regular schedule: Take Nolvadex at the same time(s) each day to help establish a routine. This can make it easier to remember to take your medication.
  6. Continue treatment as directed: It is important to complete the full course of treatment with Tamoxifen, even if you start feeling better.


The following are general guidelines for the dosage of Nolvadex:

Treatment of breast cancer:

  • Adjuvant therapy: The recommended dose is usually 20 mg to 40 mg of Nolvadex taken once daily for 5 years.
  • Metastatic or advanced breast cancer: The dosage may range from 20 mg to 40 mg of Nolvadex taken once or twice daily.

Prevention of breast cancer:

  • High-risk women: The recommended dose is usually 20 mg of Nolvadex taken once daily for 5 years.
  • Pre- and postmenopausal women may have different dosing regimens.

Off-label uses:

  • Dosage for other conditions, such as infertility or gynecomastia, may vary.

Side effects

Common side effects of Nolvadex include:

  1. Hot flashes: Many people taking Nolvadex may experience episodes of sudden warmth, flushing, and sweating, often accompanied by a rapid heartbeat.
  2. Menstrual changes: Medicine can affect menstrual periods in premenopausal women. This may include irregular periods, changes in flow, or complete cessation of periods.
  3. Vaginal discharge or dryness: Some individuals may experience changes in vaginal discharge or dryness while taking Nolvadex.
  4. Nausea and vomiting: Tamoxifen can sometimes cause feelings of nausea or lead to vomiting in some individuals.
  5. Fatigue: A sense of tiredness, weakness, or general fatigue may occur during Nolvadex treatment.
  6. Mood changes: Drug may affect mood and emotions, leading to changes such as mood swings or feelings of depression or anxiety.
  7. Bone or tumor pain: In some cases, Nolvadex can cause bone or tumor pain.
  8. Blood clots: There is a potential risk of blood clot formation with Nolvadex, which may manifest as swelling, pain, or redness in the legs or shortness of breath.
  9. Other less common side effects may include changes in liver function, changes in blood cell counts, and changes in lipid levels.


When it comes to storing Nolvadex, it is important to follow proper storage guidelines to ensure the medication remains safe and effective. Here are some general recommendations for storing:

  1. Store at room temperature: Keep Nolvadex at a temperature between 68°F (20°C) and 77°F (25°C). Avoid storing it in areas that are excessively hot, cold, or humid, such as the bathroom or kitchen.
  2. Protect from light: Keep medicine in its original container, which is designed to protect it from light. Exposure to direct sunlight or excessive light can potentially degrade the medication.
  3. Keep away from moisture: Protect drug from moisture, as it can affect the stability and effectiveness of the medication. Store it in a dry place and avoid storing it in areas with high humidity, such as the bathroom.
  4. Keep out of reach of children and pets: Store Nolvadex in a secure location, out of the reach of children and pets, to prevent accidental ingestion.
  5. Do not transfer to a different container: It is recommended to keep tablets in its original container with the original label intact. Do not transfer the tablets to a different container unless instructed to do so by a pharmacist.
  6. Check expiration date: Always check the expiration date on the Tamoxifen packaging before use. Do not use the medication if it has expired. Properly dispose of expired or unused Nolvadex according to local regulations.

Following these storage guidelines will help ensure the stability and effectiveness of Nolvadex.


An overdose of Tamoxifen can potentially lead to serious complications. Here are some general points regarding overdose:

  1. Symptoms: The specific symptoms of a Nolvadex overdose may vary depending on the amount taken and individual factors. Possible symptoms may include dizziness, severe drowsiness, confusion, unsteadiness, fainting, or irregular heartbeat.
  2. Seek medical help: If you suspect you have taken too much Nolvadex, contact your local emergency services or go to the nearest emergency room right away. It is important to provide them with information about the medication and the amount you have taken.
  3. Treatment: In cases of Nolvadex overdose, medical professionals will assess your condition and provide appropriate treatment. This may include measures to remove the medication from your system or supportive care to manage any symptoms or complications that arise.

It is crucial to remember that an overdose of Nolvadex can be serious and should be treated as a medical emergency. Prompt medical attention is vital to ensure your safety and well-being.

Missed Doses

If you miss a dose of Nolvadex, follow these general guidelines:

  1. Take the missed dose as soon as you remember: If it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
  2. Follow your regular dosing schedule: It is important to maintain a consistent dosing routine to ensure the medication's effectiveness.
  3. Set reminders: To help you remember to take your doses, consider setting reminders on your phone, using a pill organizer, or incorporating Nolvadex into your daily routine at a specific time.
  4. Do not compensate for missed doses: Do not try to "catch up" by taking extra doses of Nolvadex.

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