Sinemet is a type of combination medicine containing the drugs levodopa and carbidopa. This medication is mainly used for the treatment of Parkinson′s disease that includes shaking, tremors, movement, or stiffness related problems.
Other Parkinson′s-like symptoms that are seen after encephalitis (inflammation of the brain), or any injury caused to the nervous system by heavy metal poisoning or carbon monoxide can be treated with the help of this prescription drug.
Composition of sinemet
There is a combination of carbidopa and levodopa in the drug sinemet. Carbidopa is a type of inhibitor of aromatic amino acid decarboxylation. It is a white coloured crystalline compound that is to some extent soluble in water.
Levodopa is a white coloured crystalline compound and aromatic amino acid. It is faintly soluble in water as carbidopa. The inactive ingredients in sinemet are as follows:
• Microcrystalline cellulose
• Pregelatinized starch
• Magnesium stearate
• Hydroxypropyl cellulose
• FD&C Blue #2/Indigo Carmine AL
• D&C Yellow #10 Lake
Uses of sinemet
This medication is used for treating Parkinson′s-like symptoms or symptoms associated with Parkinson′s disease (like stiffness, shakiness, difficulty moving).
The less amount of dopamine secretion in the brain is thought to cause Parkinson′s disease. Levodopa converts into dopamine in the brain which helps in controlling movement. The breakdown of levodopa is prevented by carbidopa (stops the entry of levodopa in the bloodstream). This process helps in allowing more levodopa to enter the brain. Some side-effects like vomiting and nausea can be reduced by the help of carbidopa.
Side-effects of sinemet
There are various side-effects associated with the use of sinemet which may require medical attention. Some of these side-effects are as follows:
• Uncontrolled repetitive movements, twitching, and twisting of the lips, arms, legs, tongue, or face
• Cloudy or bloody urine
• Bladder pain
• Chest pain
• Painful, difficult, or burning urination
• Feeling empty or sad
• Unable to move the eyes
• Frequent urge of urinating
• Increased spasms or blinking of the eyelid
• Lack of appetite
• Side or lower back pain
• Loss of pleasure or interest
• Tongue sticking out
• Trouble in concentrating
• Trouble in swallowing, breathing, or speaking
• Uncontrolled twisting actions of the arms, trunk, legs, or neck
• Tarry, black stools
• Blurred vision
• Bluish colour
• Chest discomfort
• Changes in the colour of the skin
• Dry mouth
• Hoarseness or cough
• High fever
• Pounding, racing, irregular, or fast racing pulse or heartbeat
Contraindications of Sinemet
People having any of the following conditions should not be allowed to use sinemet:
• Allergy to carbidopa/levodopa
• Liver problems
• Kidney disease
• Lung disease
• Closed Angle Glaucoma
Sinemet and pregnancy
It is not yet known if sinemet is harmful to the unborn child. But breastfeeding the new born should be refrained if the patient is taking Sinemet.
5mg x 240 Tabs
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